Enzyme catalysing DNA recombination

Enzyme catalysing DNA recombination

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Credit: LAGUNA DESIGN/SCIENCE PHOTO LIBRARY

Caption: Enzyme catalysing DNA recombination. Computer model showing the molecular structure of the enzyme CRE (cyclization recombination) recombinase (small coloured spheres) mediating the recombination of strands of DNA (deoxyribonucleic acid, large coloured spheres) at a Holliday Junction. Recombination is a natural genetic process known as crossing over, and involves the mixing of two strands of DNA. Recombinase enzymes snip open each DNA strand, starting the process going and forming a four-way alignment known as a Holliday Junction. It is this structure that other recombinases, like CRE, attach to as they continue the process.

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