Human insulin monomeric form, computer generated model based upon the Protein Data Bank coordinates for entry 2HIU. Circulating, and biologically active, insulin is monomeric. It is composed of two polypeptide chains: chain A (blue) has 21 amino acids and chain B (red) has 30 amino acids (in humans). Two disulfide bridges (residues A7 to B7, and A20 to B19) covalently tether the chains, and chain A contains an internal disulfide bridge (residues A6 to A11). Superimposed upon the 2 chains are the individual amino acids (shown as ball and stick models) that make up the chains.
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