Muscle myoblast (primitive embryonic muscle cell) secreting extracellular matrix (ECM), coloured scanning electron micrograph (SEM). Skeletal muscle fibres are made when myoblasts fuse together. As a result muscle fibres have multiple nuclei. The ECMis a complex structural tissue component surrounding and supporting cells in mammalian tissues. The ECM is often referred to as the connective tissue. Many cells bind to components of the ECM. The cell to ECM adhesion is regulated by specific cell surface cellular adhesion molecules (CAM) known as integrins. The integrins transmit mechanical stimuli from the ECM to the cytoskeleton. Magnification: x5,000 when shortest axis printed at 25 millimetres.
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