Trimethoprim. Computer-generated molecular model of trimethoprim (molecular formula: C14.H18.N4.O3), an antibiotic used to treat urinary tract infections. It is composed of carbon (light blue), hydrogen (white), nitrogen (dark blue) and oxygen (red). Trimethoprim works by inhibiting the synthesis of folic acid (folate) inside the bacterial cell. Folic acid is necessary for the production of genetic material (deoxyribonucleic acid, DNA). Without DNA, the bacteria cannot reproduce and the infection is stopped (bacteriostatic effect). Trimethoprim's efficiency is being affected by the increase in bacterial resistance.
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