THC antagonist and CB1 receptor, molecular model

THC antagonist and CB1 receptor, molecular model

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Credit: RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Caption: THC antagonist and cannabinoid receptor. Computer-generated molecular model of a cannabinoid receptor 1 (CB1) complex (brown coils) with a molecule of the tetrahydrocannabinol (THC) antagonist AM6538 (green, red and white). CB1 is a cell membrane receptor found mainly in the nervous system. The natural neurotransmitter anandamide and THC, the principle psychoactive constituent of cannabis, both bind to the CB1 receptor, inducing cellular responses and playing a role in memory, regulation of feeding behaviour and motivation. AM6538 inhibits the binding of both anandamide and THC. CB1 is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders.

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