Small interfering RNA complex

Small interfering RNA complex

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Credit: LAGUNA DESIGN/SCIENCE PHOTO LIBRARY

Caption: Small interfering RNA (siRNA) complexed with PAZ domain. Computer model showing the structure of the PAZ domain (cyan) of the eukaryotic translation initiation factor 2C 1 complexed to a siRNA (ribonucleic acid, pink). RNA silencing is the degradation of targeted RNA molecules to regulate gene expression or as an antiviral defence. Double-stranded molecules of the targeted RNA are processed into short single-stranded molecules called small interfering RNAs. These siRNAs recognise and bind to complementary RNA molecules, which are then cleaved to make them inactive.

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