Tumour suppressor p73 protein and DNA

Tumour suppressor p73 protein and DNA

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Credit: LAGUNA DESIGN/SCIENCE PHOTO LIBRARY

Caption: Tumour suppressor protein p73 and DNA. Molecular model of the tumour suppressor protein p73 (left and right) bound to a segment of DNA (deoxyribonucleic acid, down centre). Like the similar p53, p73 prevents the proliferation of cells with damaged DNA. Its production occurs in response to radiation and chemicals that damage the structure of DNA. The protein binds to specific sequences in the DNA and halts the cell cycle (the means by which cells replicate). If there is only minor damage p73 activates genes involved in DNA repair, but if the damage cannot be repaired it initiates cell death (apoptosis). p73 plays a very important role in preventing cancer.

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