Dopamine synapse

Credit: JACOPIN/SCIENCE PHOTO LIBRARY

Caption: Synaptic cleft. At the level of the synaptic cleft, the transmission of the nerve impulse is made thanks to a neurotransmitter (in green ; released by the exocytosis of the synaptic vesicles of the upstream neuron ; example : dopamine) that links to a receptor located in the membrane of the downstream neuron (in purple ; example : dopaminergic receptor). When it becomes fixed to the receptor, the neurotransmitter (in green) enables the transmission of the nerve impulse. An antagonist (in blue), by fixing to the same bonding site that the neurotransmitter blocks the receptor ; the nerve impulse is not transmitted. It can be a competitive antagonist (reversible fixation) or an irreversible antagonist (irreversible fixation to the receptor site, by a covalent bonding).

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