Signet ring lobular breast cancer, light micrograph

Signet ring lobular breast cancer, light micrograph

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Credit: WEBPATHOLOGY/SCIENCE PHOTO LIBRARY

Caption: Signet ring lobular breast cancer. Light micrograph of a tissue sample from a form of invasive lobular breast cancer. This type of breast cancer arises in milk-producing glands (lobules) of the breast. Signet ring carcinoma (SRC) is a variant that consists of tumour cells with intracellular mucin accumulation resulting in signet ring appearance. Intracellular mucin accumulation pushes the nucleus to one side creating the signet ring cell appearance. Breast cancer is the most common cancer in women. Symptoms include painless lumps in the breast, a dark discharge from the nipple, and an indentation of the nipple. Early diagnosis can be made by mammography or self-examination. Once a cancer has spread, the prognosis is poor.

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