Philadelphia chromosome abnormality

Philadelphia chromosome abnormality

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Credit: PR. PHILIPPE VAGO, ISM/SCIENCE PHOTO LIBRARY

Caption: FISH (fluorescence in-situ hybridisation) light micrograph of the chromosomes at metaphase of cell division, in a normal cell (at left) and one with Philadelphia chromosome (translocation) in chronic myeloid leukaemia (CML). Humans have 46 chromosomes arranged in 23 pairs. Philadelphia chromosome is the result of a reciprocal translocation between chromosome 9 (red) and 22 (green); locus specific probes BCR:ABL: the fusion gene BCR/ABL generated by the translocation. Its presence is a sensitive test for this type of leukaemia.

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Keywords: 22, abnormal, cancer, cell division, chromosomes, chronic myeloid leukaemia, cml, condition, diagnosis, disease, disorder, fish, fluorescence in-situ hybridisation, g banding, gene bcr/abl, genetic, genetics, healthcare, human body, inheritance, inherited, karyotype, leukemia, light micrograph, male, man, medical, metaphase, mitosis, myelogenous, person, philadelphia chromosome, translocation

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