Corticotropin-releasing factor complex

Corticotropin-releasing factor complex

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Credit: LAGUNA DESIGN/SCIENCE PHOTO LIBRARY

Caption: Corticotropin-releasing factor (CRF) complex. Molecular model showing the structure of the human hormone and neurotransmitter CRF in complex with its receptor, corticotropin-releasing factor receptor type 1 (CRFR1). Atoms are colour-coded (carbon: grey, oxygen: red, nitrogen: blue, sulphur: yellow) with the bonds between them shown as sticks. The bimolecular interaction between CRF, a neuropeptide, and its type 1 receptor (CRFR1) is a crucial part of the stress response, and works by activating the hypothalamic-pituitary-adrenal axis.

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