88.1 MB (7.8 MB compressed)
5400 x 5700 pixels
45.7 x 48.3 cm ⏐ 18.0 x 19.0 in (300dpi)
GREG WILLIAMS / SCIENCE SOURCE / SCIENCE PHOTO LIBRARY GREG WILLIAMS / SCIENCE SOURCE / SCIENCE PHOTO LIBRARY
DNA-binding protein that inhibits DNA replication and cell division, thereby suppressing tumour growth. This model shows one of the four DNA-binding domains of p53 bound to a short segment of DNA. Two of the key protein-DNA bonding interactions are shown, both involving Arg side chains (yellow). One of the residues tucks into the minor groove of DNA. The other is part of a short helix that fits in the major groove. Mutations in p53 are believed to be involved in a many as 50% of human cancer cases. The residue that bonds in the minor groove (Arg-248) is the most common p53 site of mutation. Mutations in four other Arg residues and one Gly also contribute to tumour growth. These mutation-prone residues are shown in yellow along the protein ribbon.
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