41.7 MB (1.6 MB compressed)
5400 x 2700 pixels
45.7 x 22.9 cm ⏐ 18.0 x 9.0 in (300dpi)
GREG WILLIAMS / SCIENCE SOURCE / SCIENCE PHOTO LIBRARY GREG WILLIAMS / SCIENCE SOURCE / SCIENCE PHOTO LIBRARY
MK-1775 is a potent inhibitor of the tyrosine kinase enzyme Wee1. The Wee group of enzymes are negative regulators of the cell cycle via phosphorylation of critical enzymes that activate mitosis. MK-1775 enhances the cytotoxic effects of various anti-cancer drugs, including 5-fluorouricil. The compound is currently in Phase 2 clinical trials.
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