100.0 MB (4.6 MB compressed)
6827 x 5120 pixels
57.9 x 43.4 cm ⏐ 22.8 x 17.1 in (300dpi)
JUAN GAERTNER / SCIENCE PHOTO LIBRARY JUAN GAERTNER / SCIENCE PHOTO LIBRARY
Fungal enzyme on plasma membrane. Illustration of a cell membrane and a key metabolic fungal enzyme (blue). The enzyme is lanosterol 14 alpha-demethylase. It is essential for the biosynthesis of ergosterol, which in turn is essential for the permeability and rigidity of the fungal plasma membrane. The enzyme has an active site (centre) that contains a heme group (red) and a substrate (orange). Azole antifungal drugs are used to bind to and disrupt the active site of this enzyme.
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