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50.3 MB (50.0 MB compressed)
5000 x 3517 pixels
42.4 x 29.7 cm ⏐ 16.7 x 11.7 in (300dpi)
FRANCIS LEROY, BIOCOSMOS / SCIENCE PHOTO LIBRARY FRANCIS LEROY, BIOCOSMOS / SCIENCE PHOTO LIBRARY
Familial hypercholesterolaemia. Artwork showing the biochemical processes that take place in a case of the genetic disorder familial hypercholesterolaemia. This disorder leads to higher blood levels of 'bad' cholesterol (low-density lipoprotein, LDL) and associated cardiovascular disease. At left the normal process involves LDL vesicles (yellow) being taken up from blood vessels into cells with LDL receptors (cup-shaped). At right, in a case of familial hypercholesterolaemia, a lack of LDL receptors cuts off the uptake, leading to increased levels of LDL in the blood. The defective gene is the one that encodes the LDL receptor protein.
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