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Molecular graphic of zinc finger complex on DNA

Molecular graphic of zinc finger complex on DNA

G200/0021

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Credit

JAMES KING-HOLMES / SCIENCE PHOTO LIBRARY JAMES KING-HOLMES / SCIENCE PHOTO LIBRARY

Caption

Zinc finger blocking a gene. Computer graphic of the interaction between a zinc finger complex molecule (yellow) and a coloured strand of DNA (Deoxyribonucleic acid). A zinc finger molecule is a protein containing zinc (white spheres) which attaches to specific sites on DNA and can switch genes off. Here, the zinc finger complex is made of three zinc fingers, engineered to block a gene that causes leukaemia. Leukaemia is a blood cancer in which white blood cells multiply out of control. Gene therapy may employ zinc fingers to control many genetic diseases. Research conducted by Sir Aaron Klug and colleagues at MRC Laboratory of Molecular Biology in Cambridge, England.

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