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Gene therapy: microinjection of DNA into T-cell

Gene therapy: microinjection of DNA into T-cell

G210/0350

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Credit

PHILIPPE PLAILLY / SCIENCE PHOTO LIBRARY PHILIPPE PLAILLY / SCIENCE PHOTO LIBRARY

Caption

Gene therapy. Scientist performing DNA micro- injection technique, using a micropipette to introduce a corrective gene into a human T- lymphocyte (a white blood cell). A video micrograph showing the tip of the pipette & cell material appears on screen; the pipette is controlled by the joystick in the woman's right hand. This case involved a young girl whose immune system had collapsed because of her failure to produce an enzyme, adenosine desaminase (ADA), which controls the maturation of T-cells. Lymphocytes collected from her are treated with the gene that expresses ADA & the modified cells re-injected into a vein. Results are very good.

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