PHILIPPE PLAILLY / SCIENCE PHOTO LIBRARY PHILIPPE PLAILLY / SCIENCE PHOTO LIBRARY
Gene therapy. Light micrograph showing the micro-injection of a corrective gene (as DNA) into a human T-lymphocyte (T-cell). The tip of the pipette (seen here) is manipulated by remote control to penetrate the cell nucleus & deliver its load of DNA. This case involved a young girl whose immune system had collapsed because of her failure to produce an enzyme, adenosine desaminase (ADA), which controls the maturation of T-cells. Lymphocytes collected from her are treated with the gene that expresses ADA & the modified cells re-injected into a vein. Results are very good. Photo taken at Curie Institue, Orsay, France.
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