MAURO FERMARIELLO / SCIENCE PHOTO LIBRARY MAURO FERMARIELLO / SCIENCE PHOTO LIBRARY
DNA chromatography. Technician analysing DNA (deoxyribonucleic acid) samples by denaturing high performance liquid chromatography (DHPLC). This technique is used to identify DNA molecules that carry an alteration (mutation) in their nucleotide sequence. Nucleotides are the chemical units that make up the genetic code. The sequence of nucleotides along a DNA molecule is divided into regions, or genes, that provide the instructions for the production of proteins. An alteration in nucleotide sequence can cause abnormal protein production, resulting in disease. DHPLC assesses the differences between a normal DNA molecule and one bearing an alteration.
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