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Cleavage of DNA by designed enediyne: 3rd of 4

Cleavage of DNA by designed enediyne: 3rd of 4

G255/0055

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Credit

K.C.NICOLAOU ET AL, SCRIPPS RESEARCH INSTITUTE / SCIENCE PHOTO LIBRARY K.C.NICOLAOU ET AL, SCRIPPS RESEARCH INSTITUTE / SCIENCE PHOTO LIBRARY

Caption

Action of designed enediynes: Last of 4 molecular graphics showing the cleavage of DNA by a synthetic enediyne (at top). A number of these compounds have been designed by K.C. Nicolaou & colleagues at the Scripps Research Institute, California, to mimic the selective anticancer properties of more complex naturally- occurring relatives. The enediynes are designed with functional groups that target the DNA & trigger a series of reactions that result in its breakage. The DNA model was produced by J.Macke for a video by M.Pique entitled ENEDIYNES: CHEMICAL WARFARE AGAINST CANCER.

Release details

Model release not required. Property release not required.

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