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Lovell-Badge & two mice, one male sex-reversed

Lovell-Badge & two mice, one male sex-reversed

G352/0006

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Credit

PHILIPPE PLAILLY / SCIENCE PHOTO LIBRARY PHILIPPE PLAILLY / SCIENCE PHOTO LIBRARY

Caption

Medical Research Council scientist Robin Lovell- Badge stands by a projected photo of two mice. At right is a chromosomally-female (XX) mouse carrying the Sry-gene (sex-determining region Y gene) that has caused it to grow as a male with testes. At left is a normal male. The mice are products of joint research by the Medical Research Council and the Imperial Cancer Research Fund. Sex-reversal occurred in some female embryos that were injected with a small fragment of Y- chromosome DNA containing the Sry-gene. Sry is believed to act as a switch in the complex gene mechanism that diverts mammalian development from its usual course - the female - to the male.

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