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Computer graphics of sickle cell haemoglobin

Computer graphics of sickle cell haemoglobin

M108/0045

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Credit

PROFESSOR ARTHUR LESK / SCIENCE PHOTO LIBRARY PROFESSOR ARTHUR LESK / SCIENCE PHOTO LIBRARY

Caption

Computer graphics of the haemoglobin molecule in the diseased state of sickle cell anaemia. Sickle cell is associated with a single mutation in the haemoglobin; the large protein molecule in red blood cells that binds and transports oxygen from the lungs to the tissues. The mutation is a change at residue 6 of the beta chain from glutamic acid to valine. Haemoglobin has two beta chains both with the valine mutation, but only one can be seen here as indicated. As a result of this mutation the deoxygenated haemoglobin forms aggregates in the red blood cells, preventing them from passing through the capillaries.

Release details

Model release not required. Property release not required.

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