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Liver failure. Light micrograph of a section through a human liver with Dubin-Johnson syndrome. The liver cells have accumulated large coarse granules of a brown melanin-like pigment. This causes the liver to turn black. Dubin-Johnson is a rare benign condition that causes the partial failure of the liver to secret bilirubin into the bile canal. Instead, bilirubin is secreted into the bloodstream, which causes jaundice.
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