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LM of brain:Gertsmann-Straussler-Scheinker syndrom

LM of brain:Gertsmann-Straussler-Scheinker syndrom

M165/0160

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Credit

PROF. J.J. HAUW / SCIENCE PHOTO LIBRARY PROF. J.J. HAUW / SCIENCE PHOTO LIBRARY

Caption

Gertsmann-Straussler-Scheinker syndrome. Light micrograph of the brain of a patient suffering from Gertsmann- Straussler-Scheinker syndrome. This is an inherited prion disease which is related to Creutzfeldt-Jakob disease (CJD), the human form of mad cow disease. The brain tissue is studded with brown plaques and white gaps. The brain of such a patient will appear spongy with severe loss of tissue. Such changes will result in unsteady gait, loss of coordination, and progress- ive dementia. Patients with this syndrome have a genetic mutation in a gene which results in the production of a virus-like protein particle called a prion. Prions are linked to CJD & mad cow disease.

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