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Glycogenosis. Light micrograph of a section through the liver of a patient with glycogenosis, also known as glycogen storage disease. The cells are enlarged and full of glycogen. This is an inherited metabolic disease that leads to the accumulation of glycogen in the liver. It can be caused by defects in any one of several enzymes that are involved in glycogen synthesis or breakdown. Glycogen is the main carbohydrate energy store in humans. It is produced from glucose and primarily stored in the liver and muscles. Treatment depends on the type of glycogenosis, but involves following a specialised diet, with regular intake of food and avoidance of exercise.
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