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Huntington's disease

Huntington's disease

M170/0344

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Credit

FREDERIC SADOU, ISM / SCIENCE PHOTO LIBRARY FREDERIC SADOU, ISM / SCIENCE PHOTO LIBRARY

Caption

Huntington's disease. Immunofluorescent light micrograph of a nerve cell (neurone) from the striatum of the brain. An immunofluorescent antibody specific to the mutant protein, huntingtin, that causes Huntington's disease has been added to show where it is expressed. Huntington's is a genetic neurodegenerative disease. The mutant protein is due to a CAG repeat mutation on chromosome 4. The protein causes sticky plaques (accumulations of the protein) in the brain that lead to neuronal loss, which causes involuntary movements and progressive dementia. There is no cure and drugs only alleviate symptoms in the short-term.

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