ASTRID & HANNS-FRIEDER MICHLER / SCIENCE PHOTO LIBRARY ASTRID & HANNS-FRIEDER MICHLER / SCIENCE PHOTO LIBRARY
Light micrograph of human cardiac muscle following infarction. In longitudinal section, the muscle fibres (lilac) run horizontally. Abnormal features are loss of organisation in the fibres, reduced numbers of nuclei (purple) and increased space (white) between the fibres, representing interstitial oedema. The small round cells stained red at top and bottom are neutrophils infiltrating the oedematous interstitium. Together with macrophages, neutrophils represent an early inflammatory response; they serve to remove the necrotic tissue prior to scar formation. Magnification x50 at 35mm size.
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