JOHN RADCLIFFE HOSPITAL / SCIENCE PHOTO LIBRARY. JOHN RADCLIFFE HOSPITAL / SCIENCE PHOTO LIBRARY.
Lyme disease rash. A circular rash on a female patient's lower left leg known as Erythema chronicum migrans (ECM). The rash is associated with Lyme disease arthritis, an asymmetrical arthritis which involves a few large joints that was first described in Connecticut in 1972. This epidemic form of arthritis follows 1-24 weeks after the rash and was first believed to be caused by an arbovirus transmitted by a tick of the genus Ixodes. Current evidence (1987) suggests that the tick-borne agent is a spirochaete bacterium. Penicillin or tetracycline given at the time of the rash may prevent arthritis developing.
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