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Typhoid nodules, light micrograph

Typhoid nodules, light micrograph

M270/0357

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Credit

STEVE GSCHMEISSNER / SCIENCE PHOTO LIBRARY STEVE GSCHMEISSNER / SCIENCE PHOTO LIBRARY

Caption

Typhoid nodules, coloured light micrograph. Section through a lymph node of a patient with typhoid, showing macrophages (large cells, pink) forming typhoid nodules. Typhoid is a disease caused by the bacterium Salmonella typhi and is transmitted by contaminated food and water. Macrophages normally engulf and destroy pathogens found in the lymph fluid. However, S. typhi is adapted to avoid destruction and infects the macrophage that engulfs it. The infected macrophages then aggregate within tissues to form typhoid nodules. If not treated with antibiotics, these can lead to internal bleeding and death.

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