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Karyotype of chromosomes in Down's syndrome

Karyotype of chromosomes in Down's syndrome

M352/0002

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Credit

L. WILLATT, EAST ANGLIAN REGIONAL GENETICS SERVICE / SCIENCE PHOTO LIBRARY L. WILLATT, EAST ANGLIAN REGIONAL GENETICS SERVICE / SCIENCE PHOTO LIBRARY

Caption

Karyotype showing the arrangement of chromosomes in a male with Down's syndrome (trisomy-21), the most common diagnosable cause of mental handicap. Down's syndrome is caused by a chromosomal anomaly: the 21st set having three rather than the normal two chromosomes. In karyotyping, chromosomes are arranged in numbered pairs according to a standard classification. The male set differs from the female in the sex pair (bottom right); a female would have XX rather than XY. A male Down's karyotype is written: 47,XY,+21. The normal chromosome count is 46, 23 from maternal and 23 from paternal origin.

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