KENNETH EWARD / BIOGRAFX / SCIENCE PHOTO LIBRARY KENNETH EWARD / BIOGRAFX / SCIENCE PHOTO LIBRARY
Pharmaceutical uptake in the human body, mediated by drug transporters located on the plasma membranes of cells in specific target organs. These transporters permit entry of drug molecules into cells via centrally-located pores. The administration of one type of drug to a patient can affect the efficacy of a second prescription if both drugs use the same transporter, because a single type of drug transporter is often responsible for the uptake of many kinds of drugs. Further, alterations in the expression or function of that transporter can result in multidrug resistance.
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