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LM of cervical smear showing severe dysplasia

LM of cervical smear showing severe dysplasia

M850/0024

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Credit

SCIENCE PHOTO LIBRARY. SCIENCE PHOTO LIBRARY.

Caption

Light micrograph of a cervical smear showing abnormal squamous epithelial cells constituting a pre-invasive cancerous lesion. The individual cells are severely dysplastic, being pleomorphic (ie of heterogenous form), with large nuclei that show evidence of cell divisions. Normally the superficial squamous cells would appear uniform with large cytoplasms and small centrally-place nuclei, with cell division confined to basal layer. The degrees of dysplasia range from mild through moderate to severe and c.i.s., and are graded CIN I, II and III respectively. Magnification: X 160 at 35mm size.

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