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Light micrograph from a vaginal smear showing abnormal squamous epithelial cells constituting a case of carcinoma-in-situ (c.i.s.), or non- invasive cancer of the cervix. The individual cells are severely dysplastic, being pleomorphic (ie of heterogenous form), with large nuclei that show evidence of cell divisions. Normally the superficial squamous cells would appear uniform with large cytoplasms and small centrally-place nuclei, with cell division confined to basal layer. The degrees of dysplasia range from mild through moderate to severe and c.i.s., and are graded CIN I, II and III respectively. Magnification: X 160 at 35mm size.
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