DON FAWCETT / SCIENCE PHOTO LIBRARY DON FAWCETT / SCIENCE PHOTO LIBRARY
Transmission electron micrograph (TEM) of a human mast cell in connective tissue. The large oval structure in centre is the nucleus, containing the cell's genetic material. The cytoplasm contains numerous granules (dark stain) which are released in response to inflammation or allergy. The granules contain heparin, histamine & serotonin. Heparin is an anti-coagulant; histamine increases the permeability of blood vessel walls. Release of granule contents probably occurs where there is a tendency for blood clot formation, or as part of the body's general defence mechanism at sites of infection. Magnification@ x7500 at 10 centimetres wide.
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