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West Nile virus bound by human antibodies, animated model. West Nile virus can cause fever or potentially fatal meningitis or encephalitis in humans, although many cases do not cause symptoms. The reservoir of the virus is in birds, and it is transmitted by the bites of infected mosquitoes. West Nile virus is a Flavivirus, containing positive-sense single-stranded RNA genetic material. In this model, the virus has been bound and inactivated by Fab fragments of the human monoclonal antibody CR4354. The antibody prevents infection by blocking the fusion of the virus with its target cell.
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