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Cyclosporin drug molecule complex

Cyclosporin drug molecule complex

C012/4528

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Credit

RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY

Caption

Cyclosporin drug molecule complex. Computer model showing a molecule of the immunosuppressant drug cyclosporin (coloured spheres) bound to a cyclophilin protein (grey). Cyclosporin is widely used in organ transplant to reduce the risk of organ rejection. It reduces the activity of the immune system by interfering with the activity of T cells. Cyclophilins are a family of proteins from vertebrates and other organisms that bind to cyclosporin. Cyclosporins were originally isolated from fungi where they are a group of biologically active metabolites.

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