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Thymidylate synthetase molecule

Thymidylate synthetase molecule

C012/4540

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Credit

RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY

Caption

Thymidylate synthetase inhibition. Computer model showing molecules of human thymidylate synthetase (hTS) being inhibited by a thymidylate synthetase inhibitor peptide (red and spheres) bound to the active sites. TS is the enzyme used to generate thymidine monophosphate (thymidylate), which is subsequently phosphorylated to thymidine triphosphate for use in DNA synthesis and repair. It is also a target for anti-cancer chemotherapy treatments, as seen here.

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