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Whipple's disease. Light micrograph of a section through the duodenum (part of the small intestine) of a patient with Whipple's disease. This disease is caused by the bacterium Tropheryma whippelli. Although it mainly affects the intestines it may also affect the heart, lungs, joints and brain. In the intestines it causes malabsorption of nutrients, leading to weight-loss and nutritional deficiencies. Other symptoms include diarrhoea, abdominal pain, loss of appetite and fatigue. Treatment is with antibiotics. Magnification: x560 when printed at 10 centimetres wide.
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