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Enzyme catalysing DNA recombination

Enzyme catalysing DNA recombination

C014/2824

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Credit

LAGUNA DESIGN / SCIENCE PHOTO LIBRARY LAGUNA DESIGN / SCIENCE PHOTO LIBRARY

Caption

Enzyme catalysing DNA recombination. Molecular model of the enzyme CRE (cyclization recombination) recombinase (green and blue) mediating the recombination of strands of DNA (deoxyribonucleic acid, pink and orange) at a Holliday Junction. This recombination is a natural genetic process known as crossing over, and involves the mixing of two strands of DNA. Recombinase enzymes snip open each DNA strand, starting the process going and forming a four-way alignment known as a Holliday Junction. It is this structure that other recombinases, like CRE, attach to as they continue the process.

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