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Beta secretase enzyme, molecular model

Beta secretase enzyme, molecular model

C015/1974

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Credit

RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY

Caption

Beta secretase enzyme, molecular model. The enzyme (depicted by an electron density cloud, grey) is bound to an inhibitor molecule (coloured, see C015/1977). This enzyme, of the type known as aspartic-acid protease, is also known as beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It is a transmembrane protein that is thought to play a role in Alzheimer's disease through the build up of amyloid plaques in the brain. Drugs that inhibit this enzyme may help slow the progress of the disease.

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