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Notch transcription, molecular model

Notch transcription, molecular model

C015/1985

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Credit

RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY RAMON ANDRADE 3DCIENCIA / SCIENCE PHOTO LIBRARY

Caption

Notch transcription. Molecular model showing a strand of DNA (deoxyribonucleic acid) being acted upon by various proteins and other molecules. The main proteins are transcription factor CSL (blue) and the Notch 1 intra-cellular receptor or domain (white). Both are bound to a specific DNA sequence named HES1 promoter (Hairy and Enhancer of Split-1). The CSL-Notch interaction is stabilized by interaction with transcriptional co-activator Mastermind-like protein (MAML, orange, lower left). This transcription process is part of a wider cell signalling system called the notch signalling pathway.

Release details

Model release not required. Property release not required.

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