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40.9 x 30.7 cm ⏐ 16.1 x 12.1 in (300dpi)
LAGUNA DESIGN / SCIENCE PHOTO LIBRARY LAGUNA DESIGN / SCIENCE PHOTO LIBRARY
Type II topoisomerase bound to DNA, Molecular model of human topoisomerase 2-alpha (blue, a form of type II topoisomerase) forming a complex with a strand of DNA (deoxyribonucleic acid, green and purple). The topoisomerase enzymes assist in uncoiling DNA. DNA is usually stored in a supercoiled form, which must be unravelled before it can be replicated or translated into proteins. Type I topoisomerase changes the linkage in multiples of one, while Type II changes the linkages in steps of two.
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