JAMES KING-HOLMES / SCIENCE PHOTO LIBRARY JAMES KING-HOLMES / SCIENCE PHOTO LIBRARY
A micro-engineered device, developed at the University of Southampton, which will hold an individual 1 millimetre-long Caenorhabditis elegans nematode making it possible to record the neuronal 'brain' activity of these microscopic creatures. It is hoped to use the device as a high-throughput screening technology for neuroactive and neurotoxic compounds. The device prototype, shown here, uses an optimised microfluidic chamber where micro-valves introduce one nematode at a time into a precision engineered channel where it is held in place whilst neuronal activity is measured under various conditions. The device was developed by multidisciplinary team of engineers and neuroscientists at the University of Southampton's Life Sciences Institute led by Professor Lindy Holden-Dye.
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