JAMES KING-HOLMES / SCIENCE PHOTO LIBRARY JAMES KING-HOLMES / SCIENCE PHOTO LIBRARY
False-colour image of a 1 millimetre-long nematode worm, Caenorhabditis elegans being held securely, but without causing it damage, in a device developed at the University of Southampton which allows scientists to record the neuronal 'brain' activity of these tiny creatures. It is hoped such information can be used as a high-throughput screening technology for neuroactive and neurotoxic compounds.The device, the size of a microscope slide, was developed by a multidisciplinary team of engineers and neuroscientists at the University of Southampton's Life Sciences Institute led by Professor Lindy Holden-Dye. Electronics engineer Chunxiao Hu optimised the microfluidic chamber which uses a series of micro-valves. This introduces one nematode at a time into a precision engineered channel where it is held in place whilst neuronal activity is measured under various conditions.
Model release not required. Property release not required.