25.7 MB (3.0 MB compressed)
3673 x 2448 pixels
31.0 x 20.8 cm ⏐ 12.2 x 8.2 in (300dpi)
ISM / SCIENCE PHOTO LIBRARY ISM / SCIENCE PHOTO LIBRARY
Superficial pemphigus. Light micrograph of a section through a blister on the skin of a patient with pemphigus. Pemphigus is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. It causes autoantibodies to attack desmoglein, the 'glue' that attaches adjacent epidermal (skin) cells via points called desmosomes. When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes 'unglued' (acantholysis). This causes blisters that slough off and turn into sores. Magnification: x280, when printed 10 centimetres wide.
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