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Dilated cardiomyopathy, animation

K003/8652

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Credit

SCI-VIS IFC-CNR / SCIENCE PHOTO LIBRARY SCI-VIS IFC-CNR / SCIENCE PHOTO LIBRARY

Caption

Animation of incomplete calcium ion reuptake due to abnormal sarcoplasmic reticulum (SR) in a heart cell affected by dilated cardiomyopathy (DCM). Impaired function of the SERCA calcium ion pumps (spikes in foreground) is a characteristic molecular defect in DCM heart cells. The inefficiency of the SERCA means that calcium ions (white dots) are not fully cleared from the intracellular space, preventing a full relaxation of the heart cells at diastole. This is evident in the blue ECG trace (top right) which shows an incomplete relaxation phase.

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Clip Properties:

  • Duration: 00:00:55
  • Audio: No
  • Original Frame Size: 720x486
  • Interlaced: Yes
  • Capture Format: QuickTime Animation
  • Codec: Photo - JPEG

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