PHIL DEGGINGER / SCIENCE PHOTO LIBRARY PHIL DEGGINGER / SCIENCE PHOTO LIBRARY
Uracil, found in RNA, base pairs with adenine and replaces thymine during DNA transcription. Methylation of uracil produces thymine. It turns into thymine to protect the DNA and to improve the efficiency of DNA replication. Uracil can base pair with any of the bases depending on how the molecule arranges itself on the helix, but readily pairs with adenine because the methyl group is repelled into a fixed position. Uracil pairs with adenine through hydrogen bonding. Uracil is the hydrogen bond acceptor and can form two hydrogen bonds. Uracil can also bind with a ribose sugar to form a ribonucleoside, uridine. When a phosphate attaches to uridine, uridine 5'-monophosphate is produced.
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