EVAN OTO / SCIENCE PHOTO LIBRARY EVAN OTO / SCIENCE PHOTO LIBRARY
A molecular ribbon model of estrogen receptor alpha, a protein encoded by the ESR1 gene, found primarily in the endometrium, breast cancer cells, ovarian stroma cells and hypothalamus. After activated by estrogen hormones, estrogen receptors bind to DNA to regulate gene expression. Clinically, an over-expression of estrogen receptors are found in most cases of breast cancer, as receptors stimulate the replication of mammary cells, leading to increased chances for mutation and tumor formation.
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