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Histiocytosis. Light micrograph of a section through the skin (dermis) showing proliferation of Langerhans cells. These are cells that are part of the immune system. They are present in the skin and mucosa (lining) of body tissues. Langerhans cell histiocytosis (LCH) is a rare disease that occurs when Langerhans cells proliferate abnormally and migrate from the skin to lymph nodes. Symptoms include bone lesions, fever, lethargy, skin rash, and multisystem disease. This is due to the general inflammatory response triggered by the disease. Treatment is with chemotherapy and steroids. Magnification: x1,200 when printed 10 centimetres wide.
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