JEAN-DENIS LAREDO / ISM / SCIENCE PHOTO LIBRARY JEAN-DENIS LAREDO / ISM / SCIENCE PHOTO LIBRARY
Fibrous dysplasia of the skull, computed tomography (CT) scan. This is an extremely rare developmental abnormality with no known cause. It results in solid bone being replaced with weaker fibrous material (pale blue, left). Symptoms include aching and tender bones with a tendency to fracture easily. It can be monostotic (affecting only one bone, known as Jaffe-Lichtenstein disease) or polyostotic (affecting several bones independently), with the most severe form being known as McCune-Albright Syndrome.
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